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“A Novel Probiotic Platform Therapy for the Treatment of Clostridium difficile Infection”

INDIANAPOLIS–(BUSINESS WIRE)–Scioto Biosciences, a preclinical stage company developing innovative therapies to transform the delivery of microbiome therapeutics, today announced the presentation of data showing significant reduction of incidence and severity of experimental Clostridium difficile infection (CDI) and improved survival in mice using its novel live bacterial therapeutics delivery system in which bacteria are given via a successful single dose, single strain intervention.

“The study shows that our novel bacterial delivery platform, in which Lactobacillus reuteri (Lr) is adhered to microspheres leading to increased biofilm formation, significantly reduces the incidence and severity of experimental Clostridium difficile infection, and may be beneficial in preventing clinical Clostridium difficile infections in the future”

The presentation, A Novel Probiotic Platform Therapy for the Treatment of Clostridium difficile Infection, was presented by Rita Shelby, MD, Surgery Resident at The Ohio State University, at the American Academy of Pediatrics National Conference & Exhibition on Saturday, Nov. 3 in Orlando. The study also included insight from three of Scioto’s scientific founders, Michael Bailey, PhD; Steven D. Goodman, PhD; Gail E. Besner, MD FACS, as well as Natalie Tengberg, BS; Jacob Olson, MD; Miriam Conces, MD; Jason Navarro; Jacob Allen, PhD; and Yijie Wang, MS.

This study performed at the Research Institute of Nationwide Children’s Hospital sought to evaluate the effect of Scioto’s lead formulation SB-121 on the incidence and severity of CDI, the most common cause of antimicrobial-associated diarrhea affecting all patient populations across healthcare centers worldwide. The Scioto platform takes advantage of the bacteria’s activated or ‘biofilm’ state. In doing so, the platform is able to increase both the potency and efficacy of the therapeutic bacteria.

“The study shows that our novel bacterial delivery platform, in which Lactobacillus reuteri (Lr) is adhered to microspheres leading to increased biofilm formation, significantly reduces the incidence and severity of experimental Clostridium difficile infection, and may be beneficial in preventing clinical Clostridium difficile infections in the future,” explained Gail E. Besner, MD FAAP, FACS, Chief of Pediatric Surgery at Nationwide Children’s Hospital and Scientific Co-founder of Scioto Biosciences.

Affecting over 450,000 patients with 29,000 deaths a year, CDI is associated with annual excess medical costs of $4.8 billion.

The American Academy of Pediatrics National Conference & Exhibition is the premier venue for pediatric health care professionals to come together and share their passion for the health of all children. The meeting draws more than 15,000 attendees and offers over 350 sessions in 70 topic areas from interactive, hands-on workshops to high-level plenary sessions.

About Scioto Biosciences

Based in Indianapolis, Scioto Biosciences is a preclinical stage company developing innovative therapies devoted to having a transformative impact on the delivery of live bacterial therapeutics (LBTs). Scioto was founded in 2017 as a partnership between Indiana business accelerator, Monon Bioventures (MBV) and The Research Institute at Nationwide Children’s Hospital (RINCH), with whom the company has a worldwide exclusive licensing agreement. The Scioto Activated Bacterial Therapeutic Platform has the potential to enhance efficacy wherever LBTs are used such as diabetes, neurological disorders, gastrointestinal health, alternatives to in-feed antibiotics (in livestock) and others. View the original press release on BusinessWire